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Capecitabine is an orally administered precursor of 5′-deoxy-5-fluorouridine that was rationally designed to generate 5-fluorouracil (5-FU) preferentially in tumor tissue. The drug enables chronic dosing that mimics continous infusion of 5-FU. Phase II trials of capecitabine at 1250 mg/m 2 twice daily for 14 days followed by 7 days of rest, is active in anthracycline- and taxane-pretreated...
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