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Targeted protein upregulation by modulating the interaction between a target protein and its E3 ligase is the strategy opposite to targeted protein degradation (PROTAC). In their Research Article (e202300978), Dong‐Sup Lee, Seung Bum Park enhanced the cellular STING levels by inhibiting STING‐TRIM29 interaction, which activates innate immune responses in the tumor microenvironment and potentiates...
Modulating target proteins via the ubiquitin‐proteasome system has recently expanded the scope of pharmacological inventions. Stimulator of interferon genes (STING) is an auspicious target for immunotherapy. Seminal studies envisioned the importance of STING as well as the utility of its agonists in immunotherapy outcomes. Herein, we suggest UPPRIS (upregulation of target proteins by protein‐protein...
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