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Background and objective Contrary to what happens in adult–onset multiple sclerosis (MS), in a previous preliminary magnetic resonance imaging (MRI) study we showed only subtle normal–appearing brain tissue changes in patients with earlyonset MS. Our objective was to evaluate the presence and extent of tissue damage in the brain normalappearing white matter (NAWM) and gray matter (GM) from a larger...
In early relapsing-remitting (RR) multiple sclerosis (MS), conventional magnetic resonance imaging (MRI) has proved to be a valuable tool to assess disease activity over time. However, conventional MRI can only provide gross estimates of irreversible tissue damage within and outside such lesions. Other MR-based techniques, including magnetization transfer MRI, diffusion-weighted MRI, proton MR spectroscopy...
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