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The feasibility of using an osmotic pump in place of a syringe pump for microdialysis sampling in rat brain was investigated. The use of an osmotic pump permits the rat to be free from the constraints of the standard tethered system. The in vitro flow rates of a microdialysis syringe pump (set at 10.80μl/h) and the osmotic pump (pump specifications were 11.35μl/h) with no probe attached were compared,...
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