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Modification of nucleic acids with osmium tetroxide reagents (Os,L, such as OsO4,2,2′‐bipyridine, Os,bpy) has been applied in redox DNA labeling, in probing DNA structure as well as in studies of DNA interactions with other molecules. In natural DNA, primarily thymine residues form adducts with the Os,bpy in a structure selective manner. In this paper we introduce a new two‐step technique of DNA modification...
The cover picture shows an illustration of a two‐step DNA modification with the electroactive OsO4 2,2’‐bipyridine complex (Os,bpy), consisting in enzymatic construction of DNA bearing butyl acrylate (BA) moieties attached to U or to 7‐deaza A, followed by chemical modification of a reactive C=C double bond in the BA residue. We demonstrate modification of the BA conjugates not only in single‐stranded,...
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