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The consequences of combined transection of the sciatic and femoral nerves were investigated in mice of the ICR and C3HEB strains, Whereas all the animals of the C3HEB strain showed very clear self mutilatory behavior of the denervated limb (autotomy) none of the ICR mice showed autotomy. Further tests, using the hot plate and tail flick methods, show that C3HEB mice were more sensitive to noxious...
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