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A series of novel indazole‐based diarylurea derivatives targeting c‐kit were designed by structure‐based drug design. The derivatives were prepared, and their antiproliferative activities were evaluated against human colon cancer HCT‐116 cell line and hepatocellular carcinoma PLC/PRF/5 cell line. The antiproliferative activities demonstrated that six of nine compounds exhibited comparable activities...
A series of oral prodrugs based on the structure of gemcitabine (2′,2′‐difluorodeoxycytidine) were synthesised by introducing an amide group at the N4‐position of the cytidine ring. A total of 16 compounds were obtained, and their chemical and biological characteristics were evaluated. The half‐maximal inhibitory concentrations (IC50s) for most of these compounds were higher than that of gemcitabine...
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