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Objective
Gain‐of‐function mutations and genome‐wide association studies have linked phospholipase Cγ2 (PLCγ2) to various inflammatory diseases, including arthritis in humans and mice. PLCγ2‐deficient (Plcg2–/–) mice are also protected against experimental arthritis. This study was undertaken to test how PLCγ2 triggers autoantibody‐induced arthritis in mice.
Methods
PLCγ2 was deleted from various...
ObjectiveThe Syk tyrosine kinase plays an important role in diverse functions in hematopoietic lineage cells. Although previous in vitro and pharmacologic analyses suggested Syk to be a possible player in the development of autoimmune arthritis, no in vivo genetic studies addressing that issue have yet been reported. The aim of the present study was to test whether genetic deficiency of Syk affects...
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