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Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are relatively rare and heterogenous malignancies. Recent advances in histopathological classification according to the anatomical site of origin, proliferation rate, and extend of the disease have created a valid and powerful tool for the prognostic stratification of GEP-NETs. Chromogranin A is still the best available marker used for the biochemical...
Somatostatin and its synthetic analogs act through five specific somatostatin receptors (sstr1–5), found on the cell membrane of various tumors, including endocrine ones. Dopamine—a known neurotransmitter—acts through five membranous dopamine receptors (D1R–D5R) which have recently been found to be expressed in endocrine tumors. We evaluated the immunohistochemical expression of the sstrs and D2R...
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