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We describe the pharmacological and pharmacokinetic profiles of SCH 486757, a nociceptin/orphanin FQ peptide (NOP) receptor agonist that has recently entered human clinical trials for cough. SCH 486757 selectively binds human NOP receptor (K i =4.6±0.61nM) over classical opioid receptors. In a guinea pig capsaicin cough model, SCH 486757 (0.01–1mg/kg) suppressed cough at 2, 4, and 6h post...
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