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Several antiresorptive drugs, like bisphosphonates and denosumab, are currently available for the treatment of osteoporosis due to their evidenced efficacy in reducing fracture risk at mid-term. Osteoanabolic therapies, like teriparatide, whose treatment duration is limited to 2 years, have also shown efficacy in the reduction of fracture risk. However, depending on the severity of osteoporosis and...
To evaluate bone mineral density (BMD) and bone metabolism in hypertensive postmenopausal women, and to differentiate the effect of thiazides from that of other antihypertensive agents.A community-based population of 636 postmenopausal women, 293 with hypertension (160 receiving thiazides, and 133 receiving other antihypertensive treatments), and 343 control women, were evaluated. Serum levels of...
This cross-sectional study was performed to determine the reference ranges for two bone turnover markers—aminoterminal propeptide of type I collagen (P1NP) and C-terminal telopeptide of type I collagen (β-CrossLaps, β-CTX)—in normal postmenopausal Spanish women as determined in serum by automated methods.A community-based population of 1080 healthy postmenopausal women was evaluated. Data regarding...
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