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To generate temporally controlled site‐specific somatic mutations in the mouse eye pigment epithelium, we generated a TRP1‐Cre‐ERT2 transgenic mouse line that expresses the tamoxifen‐dependent Cre‐ERT2 recombinase under the control of the tyrosinase‐related protein 1 (TRP1) promoter. Cre‐ERT2 transcripts were readily detected in the retinal pigment epithelium (RPE), and tamoxifen treatment of adult...