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Background: Notch signaling is broadly required during embryogenesis, frequently activating the transcription of two basic helix–loop–helix transcription factors, Hes1 and Hes5. But, it remains unresolved when and where Hes1 and Hes5 act alone or together during development. Here, we analyzed a Hes5‐green fluorescent protein (GFP) bacterial artificial chromosome (BAC) transgenic mouse, as a proxy...
Background: During vertebrate lens development, the lens placode in the embryonic ectoderm invaginates into a lens vesicle, which then separates from the surface epithelium, followed by two waves of fiber cell differentiation. In the mouse, multiple labs have shown that Jag1‐Notch signaling is critically required during the second wave of lens fiber cell formation. However, Notch signaling appears...
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