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Neurons develop from small, spherical precursors into the largest, most asymmetric of all metazoan cells by extending thin axonal processes over enormous distances. Although the forces for this extension have been unclear, recent work shows that the initial axonal extension may involve an unexpected mechanism: sliding of microtubules, driven by a motor protein previously thought to be deployed only...
Dynamic microtubules explore the peripheral (P) growth cone domain using F actin bundles as polymerization guides [1, 2]. Microtubule dynamics are necessary for growth cone guidance [3–6]; however, mechanisms of microtubule reorganization during growth cone turning [7–9] are not well understood. Here, we address these issues by analyzing growth cone steering events in vitro, evoked by beads derivatized...
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