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The aim of this study was to examine whether cariporide, a new inhibitor of Na + /H + exchanger 1 (NHE-1), may inhibit high glucose-induced monocyte–endothelial cell adhesion and the expression of intercellular adhesion molecule-1 (ICAM-1). Cultured endothelial cells were incubated with normal glucose control (5.5 mM), cariporide control (5.5 mM glucose plus 10 μM cariporide), hyperosmolarity...
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