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A transient hypometabolic state can be induced in mammals by 5′-AMP administration. During the hypometabolic state, core body temperature (Tb) of the animal can be readily reduced from euthermia. For example, at ambient temperature (Ta) of 15°C, the Tb of mice can be reduced to 1–2°C above Ta for 6–9h until they spontaneously returned to euthermia. We have observed that several species of non-hibernating...
A variety of mammals, including several species of ground squirrels, prairie dogs, hamsters, and marsupials, innately enter into hypometabolic states, such as hibernation and daily torpor, to reduce energy expenditure during unfavorable environmental conditions such as cold winter. The mechanism of metabolic suppression in these instances is still largely unknown. Our lab has developed a method for...
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