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A healthy 2‐year‐old girl presented with multiple asymptomatic subcutaneous nodules on both legs. Histologically demonstrated calcium deposition within the dermis and subcutaneous tissue consistent with calcinosis cutis. Laboratory abnormalities, underlying genetic conditions, and potential triggering factors were ruled out. The lesions resolved over an 18‐month period without treatment, emphasizing...
Several gain‐of‐function variants in NLRP1 cause a distinctive autoinflammatory disease reported under different names featuring mainly skin and mucosal involvement and variable systemic signs. Here, we report a new case of NLRP1‐associated autoinflammatory disease in a 6‐year‐old Peruvian girl, who presented with confluent hyperkeratotic plaques that drained purulent material with subsequent scarring...