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Die Diterpensynthase AfAS wurde aus Aspergillus fumigatiaffinis identifiziert. Ihre Aminosäuresequenz und – einem Strukturmodell zufolge – die Architektur des aktiven Zentrums sind denen der Fusicocca‐2,10(14)‐dien‐Synthase PaFS sehr ähnlich, AfAS produziert jedoch ein strukturell viel komplexeres Diterpen mit einem neuartigen 6–5–5–5 tetracyclischen Gerüst namens Asperfumen. Der Cyclisierungsmechanismus...
O‐GlcNAcylation is a dynamic, reversible and atypical O‐glycosylation that regulates various cellular physiological processes via conformation, stabilisation, localisation, chaperone interaction or activity of target proteins. The O‐GlcNAcylation cycle is precisely controlled by collaboration between O‐GlcNAc transferase and O‐GlcNAcase. Uridine‐diphosphate‐N‐acetylglucosamine, the sole donor of O...