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The somatotopic map of the first nociceptive component in the primary somatosensory cortex (S1) is still unclear. In this study, a CO 2 laser was applied to the tail of the rat to induce nociception without the interference from large myelinated (A β ) fibers. Thus, only noxious fibers could be activated. Two-dimensional current-source-density analysis was used to analyze the evoked...
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