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Despite patient selection based on ERBB2 overexpression, not all patients benefit from trastuzumab therapy. We have investigated whether a ERBB2 gene dosage effect might provoke increased biological aggressiveness and altered trastuzumab sensitivity. Absolute ERBB2 copy numbers (“CN”) and ERBB2/centromer 17 ratios (“R”) were measured by FISH analysis in tumors of 127 patients receiving trastuzumab‐based...
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