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This study examined the effect of ketoconazole on viability, apoptosis, mitogen-activated protein kinases (MAPKs) and Ca 2+ levels in MG63 osteosarcoma cells. Ketoconazole at 20–200μM decreased cell viability via apoptosis as demonstrated by propidium iodide staining and activation of caspase-3. Immunoblotting suggested that ketoconazole induced phosphorylation of ERK and JNK, but not p38,...
The effect of the antidepressant desipramine on intracellular Ca 2+ movement and viability in prostate cancer cells has not been explored previously. The present study examined whether desipramine could alter Ca 2+ handling and viability in human prostate PC3 cancer cells. Cytosolic free Ca 2+ levels ([Ca 2+ ] i ) in populations of cells were measured using...
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