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ObjectiveThe mechanism by which monosodium urate monohydrate (MSU) crystals intracellularly activate the cryopyrin inflammasome is unknown. The aim of this study was to use a mouse molecular genetics–based approach to test whether the leucine‐rich repeat (LRR) domain of cryopyrin is required for MSU crystal–induced inflammation.
MethodsCryopyrin‐knockout lacZ (Cryo−Z/−Z) mice and mice with the cryopyrin...
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