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Zn2+ inhibits the action of several of the caspases and thus may act as a regulator of apoptosis. Reversal of this inhibition is one possible approach for the development of apoptosis‐based therapies. Few studies describe the molecular details of the Zn2+–caspase interaction, the understanding of which is essential for the success of any therapeutic strategies. Enzyme kinetics and biophysical studies...
Zink‐ und Kupferionen spielen entgegengesetzte Rollen in der Apoptose, wobei Zink das proapoptotische Protein Kaspase‐3 hemmt. In der Zuschrift auf S. 4182 ff. weisen N. P. Farrell et al. nach, dass diese Kaspase‐3‐Inhibierung über eine Wechselwirkung der Zinkionen mit dem Histidinrest im aktiven Zentrum – und nicht mit der katalytischen Diade, wie zuvor angenommen wurde – erfolgt.
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