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Cell surface glycoconjugates are thought to mediate cell-cell recognition and play roles in neuronal development and functions. We demonstrated here that exposure of neuronal cells to nanomolar levels of gangliosides Neu5Acα8Neu5Acα3Galβ4GlcCer, Galβ3GalNAcβ4(Neu5Acα8Neu5Acα3)Galβ4GlcCer (GD1b), Neu5Acα3Galβ3GalNAcβ4(Neu5Acα8Neu5Acα3)Galβ4GlcCer (GT1b) or its oligosaccharide portion induced a rapid...
Cell surface glycoconjugates are thought to mediate cell-cell recognition and to play roles in neuronal development and functions. We demonstrated here that exposure of neuronal cells to nanomolar levels of glyco-chains with an N-acetylgalactosamine (GalNAc) residue at the non-reducing termini (GalNAc-S) such as GalNAcβ4(Neu5Acα3)Galβ4GlcCer (GM2) ganglioside, its oligosaccharide portion, GalNAcβ4Galβ4GlcCer...
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