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BackgroundEarly growth response‐1 (Egr‐1) protein plays an important role in many human fibrotic diseases. Areca nut chewing is the most important risk factor of oral submucous fibrosis (OSF).
MethodsEgr‐1 protein expression in OSF was examined using antibody to Egr‐1. Arecoline‐induced Egr‐1 expression and its signaling pathways were assessed by Western blot analyses in human buccal mucosal fibroblasts...
BackgroundConnective tissue growth factor (CTGF/CCN2) is associated with many human fibrotic disorders and was found to overexpress in oral submucous fibrosis (OSF). OSF is the result of persistent chemical irritation and microtrauma to oral mucosa from areca nut. Microtrauma could lead to the release of thrombin.
MethodsThrombin‐induced CCN2 expression and its signaling pathways were assessed by...
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