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BACKGROUNDGlucocorticoids influence prostate development and pathology, yet the underlying mechanisms including possible direct glucocorticoid effect on the prostate are not well characterized.
METHODSWe evaluated the expression of the glucocorticoid receptor (GR) together with the effects of supraphysiological glucocorticoid (corticosterone) on mouse prostate morphology and epithelial proliferation...
The role of endogenous glucocorticosteroids (GC) in bone development is ill-defined. Using the Col2.3-11βHSD2 transgenic (tg) mouse model, we examined the effect of osteoblast-targeted disruption of intracellular GC signalling on bone growth and strength, and its modulation by factors such as age, gender and skeletal site.Tibiae and L3 vertebrae of 3 and 7-week-old, male and female wild type (WT)...
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