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The information-intensive and interdisciplinary iterative nature of construction design projects makes it hard to plan and schedule using traditional tools. This results in inevitable rework and time waste in design process. The DSM method can handle sequential, parallel, in addition to coupled activities, and thus to optimize information flow in construction design project. In this article, a quantitative...
The applications in the area of protein engineering motivate a problem, that is to compute an mRNA sequence of maximal similarity to a given mRNA and a given protein, the output mRNA sequence should have the same secondary structure as the given mRNA sequence and should not contain any stop codon. We call this problem as MRSO-SC (MRna structure optimization under no stop codon constraint). Besides,...
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