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The chromosomal translocation t(11;22)(q24;q12) generates the EWS–Fli1 fusion gene, which contributes to the development of Ewing Family Tumors (EFTs). Although p53 mutations are found only in 5–20% of EFTs, the p53 pathway is thought to be abrogated in EFTs. The role of EWS–Fli1 in the p53 pathway in the tumor is still poorly understood. In this study, using immunoprecipitation and co-localization,...
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