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Rationale Clozapine affects the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway in the brain, which plays an important role in its antipsychotic action. However, previous findings are inconsistent, and related molecular mechanisms require further clarification. Objectives Time- and dose-dependent effects of clozapine on the ERK1/2 pathway and its regulatory mechanism were investigated...
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