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Epidermal growth factor (EGF) or transforming growth factor-α (TGF-α) stimulates cell migration, proliferation and the formation of tube-like structures of human microvascular endothelial cells in culture. Heparin-binding EGF-like growth factor (HB-EGF), which shows 35% homology with EGF/TGF-α, is a member of the EGF family, and it is ubiquitous in many tissues and organs. We examined whether or...
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