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This paper shows how a game theoretical analysis can provide a model to determine the factors affecting the switch from CXCR4 coreceptor (X4) to CCR5 coreceptor (R5) in HIV-1 infected individuals. Simulations of the model predict that a persistent immune response suppresses the X4-tropic virus to a low level at first, but later increases in the immune response will trigger the switch from X4 to R5...
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