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Tuberculosis (TB) is still one of the most common causes of death in the world. The emergence of multidrug-resistant and extensively drug-resistant (XDR-TB) Mycobacterium tuberculosis (M. tuberculosis) strains has increased the importance of searching for alternative targets to develop new antimycobacterial drugs. Linezolid, the first of oxazolidinones, is active in vitro against M. tuberculosis,...
Chelerythrine (a natural quaternary benzophenanthridine alkaloid) is an extract from the roots of Chelidoniummajus with potential antimycobacterial activity. To reveal the possible mechanism of action of chelerythrine against Mycobacteriumtuberculosis (M. tuberculosis), commercial oligonucleotide microarrays were used to analyze the genome-wide transcriptional changes triggered by treatment with...
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