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Possible adverse effects of excess intake of dietary n-3 fatty acids have been reevaluated in rats by measuring peroxisomal proliferation, mitochondrial enzyme activity and incidence of apoplexy. When Sprague-Dawley rats were fed diets containing either fish oil rich in docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) or perilla seed oil rich in α-linolenic acid for 4 or 12 weeks, DHA accumulated...
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