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The acoustic microstreaming originating from microbubbles' linear oscillations can be used as a potential cell sonoporation tool for drug delivery and gene transfection. However, this bubble-based method suffers from bubble instability, non-uniform size, unreliable performance, and inconvenient trapping. In order to overcome the above drawbacks, in this study, we proposed a massive drug delivery method...
Acoustic lenses, concentrating the acoustic energy into a specific area, have attracted interest due to their broad applications in various domains, such as biomedical imaging, nondestructive testing, etc. For waterborne sound, conventional silicone materials are fabricated with concave shape for focusing wave. However, it is not flexible to design a concave lens than a flat lens to manipulate acoustic...
We numerically report a high efficient acoustic lens using a flat artificial composite plate in water, which is designed using silicone films deposited on PMMA plate engraved with the annular grooves. The focusing effect is due to the phase of the plate changing with the height of PMMA variation, while the total height of the plate is held constant. As both PMMA and silicone are low impedance mismatch...
Ultrasound has been demonstrated to be an effective approach for noninvasive neurostimulation. Low frequency ultrasound (<1 MHz) is preferable as its low ultrasonic attenuation when passing through the skull. High frequency ultrasound is able to provide reduced size of focal region. However, the performance of stimulation with high frequency ultrasound is not proved yet. This study examines the...
The ability to manipulate microparticles or nanoparticles precisely is important for the development of microsystem. Acoustic tweezers are excellent tools for manipulating particles with size approaching or slightly smaller than wavelength. However, manipulation of microparticles with much smaller size requires stronger acoustic confinement and higher intensities than can be provided by these diffraction-limited...
Microbubble ultrasound contrast agent (UCA) has been well recognized as a potential noninvasive tool for the blood pressure measurement. A decrease in subharmonic amplitude of 9 to 12 dB has been reported for Levovist, Optison, Definity, Sonazoid, and SonoVue for ambient overpressure values around 180 mmHg. However, a pressure resolution of 3 mmHg is desirable in medical diagnostics, it is still necessary...
We theoretically and experimentally investigate the acoustic radiation force (ARF) on cylindrical steel particle near subwavelength slits. By using finite-difference-time-domain (FDTD) method combined with momentum-flux tensor, the dependence of the ARF on the frequency, width of slit are analyzed, respectively. It is predicted that the particle near the slit surface could suffer a trapping effect...
Ultrasound contrast agents (UCA) microbubbles have been well recognized as a potential noninvasive tool for blood pressure measurement. The effect of ambient pressure on UCA subharmonic optimal driving frequency (SODF), at which the subharmonic scattering signals were maximal, was investigated experimentally. For groups of microbubbles with 80.1%±1.6% in the diameter range of 1µm–2µm, the shift of...
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