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Immunolabeled tissue section of 3‐day zebrafish embryo, double mutant for the tumor suppressor Rb and chromatin adaptor Rbbp4, showing programmed cell death (green), neurons (red), and nuclei (blue) in the retina and brain. From: Rbbp4 loss disrupts neural progenitor cell cycle regulation independent of Rb and leads to Tp53 acetylation and apoptosis; Schultz‐Rogers LE, et al. https://doi.org/10.1002/dvdy...
Background
Retinoblastoma binding protein 4 (Rbbp4) is a component of transcription regulatory complexes that control cell cycle gene expression. Previous work indicated that Rbbp4 cooperates with the Rb tumor suppressor to block cell cycle entry. Here, we use genetic analysis to examine the interactions of Rbbp4, Rb, and Tp53 in zebrafish neural progenitor cell cycle regulation and survival.
Results...
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