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TGFβ signals play important roles in establishing the body axes and germ layers in the vertebrate embryo. Vg1 is a TGFβ-related gene that, due to its maternal expression and vegetal localization in Xenopus, has received close examination as a potential regulator of development in Xenopus, zebrafish, and chick. However, a mammalian Vg1 ortholog has not been identified. To isolate mammalian Vg1 we screened...
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