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ATP-stimulated P2X 1 and ADP-stimulated P2Y 1 receptors play important roles in platelet activation. An increase in intracellular Ca 2+ represents a key signalling event coupled to both of these receptors, mediated via direct gating of Ca 2+ -permeable channels in the case of P2X 1 and phospholipase-C-dependent Ca 2+ mobilisation for P2Y 1 ....
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