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Objectives To study the influence of the presence of water on the dermal absorption of 2-butoxyethanol (BE) in volunteers. Methods Six male volunteers were dermally exposed to 50%, 90% or neat w/w BE for 4 h on the volar forearm over an area of 40 cm2. An inhalation exposure with a known input rate and duration served as a reference dosage. The dermal absorption parameters were calculated from 24-h...
Objectives: To assess excretion kinetics of free and total (free + conjugated) 2-butoxyacetic acid (BAA) following dermal and inhalation exposure to butoxyethanol (BE). Methods: Six male volunteers were dermally exposed for 4 h to a 50% aqueous solution of BE on an area of 40 cm2 of the volar forearm. Six other male volunteers were exposed by inhalation (mouth only) to 93 mg m−3 BE for 30 min. As...
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