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Histone deacetylase inhibitors have been found to restore sensitivity to the estrogen receptor in endocrine-resistant and triple-negative breast cancer cell lines. We decided to test panobinostat, a pan-histone deacetylase inhibitor, because of preclinical data, combined with letrozole in a phase I study.We enrolled patients with metastatic breast cancer to determine the safety and tumor response...
We conducted a multiinstitutional phase II study of capecitabine in combination with vinorelbine and trastuzumab in patients eligible to receive first- or second-line treatment for human epidermal growth factor receptor type 2 (HER2)-positive (HER2 + ) metastatic breast cancer (MBC). The study was designed to test that the true confirmed response rate (CRR) was at most 45% vs. a true CRR...
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