The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Tumour cell populations can be thought of as a composition of heterogeneous cell subpopulations, with each subpopulation being characterized by overlapping sets of single‐nucleotide variants. Such subpopulations are known as subclones and are an important target for precision medicine. Reconstructing subclones from next generation sequencing data is one of the major challenges in computational biology...
We propose a flexible design for the identification of optimal dose combinations in dual‐agent dose finding clinical trials. The design is called AAA, standing for three adaptations: adaptive model selection, adaptive dose insertion and adaptive cohort division. The adaptations highlight the need and opportunity for innovation for dual‐agent dose finding and are supported by the numerical results...
Tissue samples from the same tumour are heterogeneous. They consist of different subclones that can be characterized by differences in DNA nucleotide sequences and copy numbers on multiple loci. Inference on tumour heterogeneity thus involves the identification of the subclonal copy number and single‐nucleotide mutations at a selected set of loci. We carry out such inference on the basis of a Bayesian...
Treating patients with novel biological agents is becoming a leading trend in oncology. Unlike cytotoxic agents, for which efficacy and toxicity monotonically increase with dose, biological agents may exhibit non‐monotonic patterns in their dose–response relationships. Using a trial with two biological agents as an example, we propose a dose finding design to identify the biologically optimal dose...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.