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Background
To determine the distribution of vancomycin into the cerebrospinal fluid (CSF) in patients with external ventricular drain (EVD)‐associated ventriculitis, the pharmacokinetics of vancomycin were evaluated and covariate relationships explored.
Methods
For the population pharmacokinetic model patients were recruited in a neurocritical care unit at the University Hospital of Muenster in...
Vancomycin (VAN) is among those antibiotics for which therapeutic drug monitoring is highly recommended. For this purpose a reliable method with small sample volume was required for quantification of VAN in human plasma. Therefore, a selective and sensitive method of high performance liquid chromatography was developed and validated. The separation was carried out isocratically by using a mobile phase...
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