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Two forms of the human 52 kDa SS-A/Ro protein autoantigen, 52α and 52β, are products of alternative mRNA splicing. The 52α form is ubiquitously expressed whereas 52β, lacking the central leucine zipper domain, has been detected at higher levels than 52α during certain stages of fetal development. Because 52α has sequence similarity with macromolecules associated with transcriptional regulation and...
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