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Jaundice is an important clinical sign reflecting the accumulation of bilirubin in blood. It is frequently associated with significant underlying disease. It can result from increased bilirubin production (due to haemolysis); inability of the liver to take up and/or conjugate bilirubin (in Gilbert’s syndrome or parenchymal liver disease); or failure to excrete bilirubin into biliary canaliculi and/or...
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