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Background
Chronic hepatitis C (CHC) is associated with systemic insulin resistance, yet there are limited data on the tissue‐specific contribution in vivo to this adverse metabolic phenotype, and the effect of HCV cure.
Methods
We examined tissue‐specific insulin sensitivity in a cohort study involving 13 patients with CHC compared to 12 BMI‐matched healthy control subjects. All subjects underwent...
Insulin resistance and lipotoxicity are pathognomonic in non-alcoholic steatohepatitis (NASH). Glucagon-like peptide-1 (GLP-1) analogues are licensed for type 2 diabetes, but no prospective experimental data exists in NASH. This study determined the effect of a long-acting GLP-1 analogue, liraglutide, on organ-specific insulin sensitivity, hepatic lipid handling and adipose dysfunction in biopsy-proven...
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