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DNA vaccines expressing Haemonchus contortus H11 antigen with or without interleukin (IL)-2 were tested for protection against H. contortus infection in goats. Sixteen goats (8–10months of age) were allocated into four trial groups. On days 0 and 14, group 1 was immunised with a DNA vaccine expressing H11 and IL-2 and group 2 was immunised with a DNA vaccine expressing H11 only. Group 3 was an unvaccinated...
Due to critical functions in worm physiology, Haemonchus contortus cysteine proteases are potential candidates for immunological control of haemonchosis. However, only limited information is available on the immunoprotective potential of these molecules in goat. In the present study, HC58 DNA vaccine, a cysteine protease of adult H. contortus worms, was evaluated for protection against homologous...
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