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Background The configuration of necrotic areas within the retinal pigmented epithelium is an important element in the progression of age-related macular degeneration (AMD). In the exudative (wet) and non-exudative (dry) forms of the disease, retinal pigment epithelial (RPE) cells respond to adjacent atrophied regions by secreting vascular endothelial growth factor (VEGF) that in turn recruits new...
Physiologically-relevant in vitro models of retinal disease are necessary for understanding the complex interactions of oxidative stress, molecular signaling and physical contact between cells and their local environment. In this study, microfluidic devices and microcontact printing are used to mimic in vivo conditions of the sub-retinal microenvironment and the effects of oxidative stress and atrophy...
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