Search results for: Kazuyoshi Okada

Items from 1 to 20 out of 32 results

article

Splenic abscess diagnosed following relapsing sterile peritonitis in a peritoneal dialysis patient: A case report with literature review

Chiaki Masaki, Kenta Matsushita, Tomoko Inoue, Hisato Shima, more

Seminars in Dialysis > 34 > 3 > 245 - 251

Peritoneal dialysis (PD)‐related peritonitis is sometimes complicated with other infections; however, few cases of splenic abscess have been reported. We present the case of a 64‐year‐old PD patient with complicated splenic abscesses diagnosed following relapsing sterile peritonitis. After PD induction, he presented with turbid peritoneal fluid and was diagnosed with PD‐related peritonitis. A plain...

article

Pulmonary sarcoidosis as a cause of intermittent fever of unknown origin in a hemodialysis patient with renal cell carcinoma: A case report and literature review

Hisato Shima, Masaaki Nishitani, Manabu Tashiro, Tomoko Inoue, more

Hemodialysis International > 23 > 2 > E53 - E58

Hemodialysis patients have weakened immune systems and can exhibit fever due to various causes. Herein, we describe the case of a 61‐year‐old hemodialysis patient who exhibited intermittent low‐grade fever after a pacemaker had been implanted 2 months before due to sick sinus syndrome. She had a medical history of subcutaneous sarcoidosis and uveitis. Active pulmonary sarcoidosis was diagnosed based...

article

Sucroferric oxyhydroxide decreases serum phosphorus level and fibroblast growth factor 23 and improves renal anemia in hemodialysis patients

Hisato Shima, Keiko Miya, Kazuyoshi Okada, Jun Minakuchi, more

BMC Research Notes > 2018 > 11 > 1 > 1-8

Objective Sucroferric oxyhydroxide, a novel iron-based phosphate-binder, has been shown to have beneficial effects in lowering serum phosphorus levels and improving renal anemia in clinical studies. Although an effect of this agent on fibroblast growth factor 23 (FGF23) has been reported in an animal study, there is little clinical data supporting this finding. This study aimed to evaluate the effect...

article

Intestinal perforation by a peritoneal dialysis catheter in which fungal peritonitis led to diagnosis: a rare case report

Hisato Shima, Shogo Mizoguchi, Yuji Morine, Manabu Tashiro, more

CEN Case Reports > 2018 > 7 > 2 > 208-210

Intestinal perforation by a peritoneal catheter is an uncommon, but serious, complication that has a high mortality rate. Intestinal perforation in peritoneal dialysis (PD) patients is difficult to diagnose using symptoms and radiological findings, which may result in a delay in diagnosis. Moreover, intestinal perforation complicated with fungal peritonitis is reportedly a severe condition with a...

article

Cilostazol-induced acute tubulointerstitial nephritis accompanied by IgA nephropathy: a case report

Hisato Shima, Manabu Tashiro, Satoshi Yamada, Motokazu Matsuura, more

BMC Nephrology > 2018 > 19 > 1 > 1-5

Background Cilostazol is an antiplatelet drug that is widely prescribed for the prevention of secondary stroke. Adverse reactions to cilostazol include headaches, palpitations, and diarrhea. Little is known about the nephrotoxicity of cilostazol, such as acute kidney injury. We report a biopsy-proven case of diffuse tubulointerstitial nephritis induced by cilostazol. Case presentation A 69-year-old...

article

Effects of a spleen tyrosine kinase inhibitor on progression of the lupus nephritis in mice

Maki Kitai, Noboru Fukuda, Takahiro Ueno, Morito Endo, more

Journal of Pharmacological Sciences > 2017 > 134 > 1 > 29-36

The Fc receptors (FcR) have pivotal roles in the pathogenesis of the autoimmune glomerulonephritis. We therefore investigated the effects of a Syk inhibitor on the progression of lupus nephritis and SH3 domain binding protein 2 and p38MAP kinase signalings in mice. NZB/W F1 mice, a model of lupus nephritis, received a Syk inhibitor R406. Western blotting and immunohistochemistry revealed that R406...

article

Efficacy and Safety of Pregabalin for the Treatment of Neuropathic Pain in Patients Undergoing Hemodialysis

Tomoyasu Otsuki, Terumi Higuchi, Toshio Yamazaki, Erina Okawa, more

Clinical Drug Investigation > 2017 > 37 > 1 > 95-102

Objective Pregabalin is a gamma aminobutyric acid derivative administered for neuropathic pain. It binds to α2δ subunits of voltage-dependent calcium channels, and inhibits calcium inflow of synapses and the release of excitatory neurotransmitters. This study investigated the efficacy and safety of pregabalin in patients with peripheral neuropathic pain undergoing maintenance hemodialysis. Methods...

article

Efficacy and safety of saxagliptin, a dipeptidyl peptidase-4 inhibitor, in hemodialysis patients with diabetic nephropathy: A randomized open-label prospective trial

Masanori Abe, Terumi Higuchi, Masari Moriuchi, Masahiro Okamura, more

Diabetes Research and Clinical Practice > 2016 > 116 > C > 244-252

Saxagliptin is a dipeptidyl peptidase-4 inhibitor that was approved in Japan for the treatment of type 2 diabetes in 2013. We examined its efficacy and safety in Japanese hemodialysis patients with diabetic nephropathy.In this prospective, open-label, parallel-group study, Japanese hemodialysis patients were randomized to receive either oral saxagliptin (2.5mg/day) or usual care (control group) for...

article

Levocarnitine Improves Cardiac Function in Hemodialysis Patients With Left Ventricular Hypertrophy: A Randomized Controlled Trial

Terumi Higuchi, Masanori Abe, Toshio Yamazaki, Erina Okawa, more

American Journal of Kidney Diseases > 2016 > 67 > 2 > 260-270

Levocarnitine deficiency in hemodialysis patients is common. Although the effect of levocarnitine therapy on uremic anemia has been studied in small trials, its effects on cardiac function remain unclear.Multicenter, prospective, open-label, parallel, randomized, controlled trial.Patients undergoing maintenance hemodialysis with carnitine deficiency (free carnitine plasma concentration < 40μmol/L)...

article

Association of restless legs syndrome with oxidative stress and inflammation in patients undergoing hemodialysis

Terumi Higuchi, Masanori Abe, Mari Mizuno, Toshio Yamazaki, more

Sleep Medicine > 2015 > 16 > 8 > 941-948

Restless legs syndrome (RLS) is a common comorbidity in patients undergoing hemodialysis, but clinical factors predictive of RLS risk and severity have not been identified. The aims of this multicenter cross-sectional study were to document RLS prevalence and severity in patients undergoing hemodialysis and to identify associated risk factors.One-hundred and fifty-nine stable patients on maintenance...

article

Proposal for the Shared Decision‐Making Process Regarding Initiation and Continuation of Maintenance Hemodialysis

Yuzo Watanabe, Hideki Hirakata, Kazuyoshi Okada, Hiroyasu Yamamoto, more

Therapeutic Apheresis and Dialysis > 19 > S1 > 108 - 117

article

Japanese Society for Dialysis Therapy Clinical Guideline for “Hemodialysis Initiation for Maintenance Hemodialysis”

Yuzo Watanabe, Kunihiro Yamagata, Shinichi Nishi, Hideki Hirakata, more

Therapeutic Apheresis and Dialysis > 19 > S1 > 93 - 107

article

Low-density lipoprotein apheresis for corticosteroid-resistant skin lesions caused by cholesterol crystal embolism: a case report and review of the literature

Hiroki Kobayashi, Masanori Abe, Yusuke Murata, Takashi Maruyama, more

Journal of Artificial Organs > 2015 > 18 > 3 > 285-289

Cholesterol crystal embolism (CCE) is an arterio-arterial embolism originating from the breakdown of atherosclerotic plaques in the aortic wall. The embolism affects the skin and kidney particularly, as well as frequently affects the gastrointestinal tract and other organs. Although there are no clearly effective direct therapies for CCE, corticosteroid therapy and combination therapy with low-density...

article

Systematic implantation of dedifferentiated fat cells ameliorated monoclonal antibody 1-22-3-induced glomerulonephritis by immunosuppression with increases in TNF-stimulated gene 6

Takashi Maruyama, Noboru Fukuda, Taro Matsumoto, Koichiro Kano, more

Stem Cell Research & Therapy > 2015 > 6 > 1 > 1-16

Introduction Implantation of mesenchymal stem cells (MSCs) has recently been reported to repair tissue injuries through anti-inflammatory and immunosuppressive effects. We established dedifferentiated fat (DFAT) cells that show identical characteristics to MSCs. Methods We examined the effects of 10⁶ of DFAT cells infused through renal artery or tail vein on monoclonal antibody (mAb) 1-22-3-induced...

article

L/N-type calcium channel blocker cilnidipine reduces plasma aldosterone, albuminuria, and urinary liver-type fatty acid binding protein in patients with chronic kidney disease

Masanori Abe, Noriaki Maruyama, Hiroko Suzuki, Atsushi Inoshita, more

Heart and Vessels > 2013 > 28 > 4 > 480-489

Cilnidipine inhibits both L- and N-type calcium channels and has been shown to dilate efferent arterioles as effectively as afferent arterioles. We conducted an open-label, randomized trial to compare the effects of cilnidipine against those of amlodipine on blood pressure (BP), albuminuria, and plasma aldosterone concentration in hypertensive patients with mild- to moderate-stage chronic kidney disease...

article

Efficacy analysis of the renoprotective effects of aliskiren in hypertensive patients with chronic kidney disease

Masanori Abe, Hiroko Suzuki, Kazuyoshi Okada, Noriaki Maruyama, more

Heart and Vessels > 2013 > 28 > 4 > 442-452

We aimed to assess the effect of aliskiren treatment on blood pressure, albuminuria, and kidney function in patients with chronic kidney disease (CKD). We conducted a prospective, open-label study of 67 patients with CKD who were already being treated with other antihypertensives. Inclusion criteria were blood pressure (BP) ≥130/80 mmHg, albuminuria ≥30 mg/g, and estimated glomerular filtration rate...

article

Aliskiren reduces home blood pressure and albuminuria in patients with hypertensive nephrosclerosis

Hiroko Suzuki, Kazuyoshi Okada, Masanori Abe, Noriaki Maruyama, more

Clinical and Experimental Nephrology > 2013 > 17 > 3 > 386-395

Background The aim of this study was to investigate the antialbuminuric and antihypertensive effects of aliskiren by monitoring home blood pressure (BP) in comparison with the effects of the angiotensin receptor blocker (ARB) valsartan in patients with hypertensive nephrosclerosis and albuminuria. Methods We conducted an open-label, randomized trial to compare the effects of aliskiren with those...

article

Platinum nanowire network with silica nanoparticle spacers for use as an oxygen reduction catalyst

Wataru Shimizu, Kazuyoshi Okada, Yoshitaka Fujita, ShanShan Zhao, more

Journal of Power Sources > 2012 > 205 > Complete > 24-31

A platinum nanowire network (approximate ∅4nm) with silica nanoparticle (Pt _net /SiO ₂ ) spacers was prepared via spray drying and hydrogen reduction. The large network had few grain boundaries of crystalline platinum and enclosed SiO ₂ nanoparticles (average ∅ 75nm). These properties contributed to thermal and chemical stability of the structure. The nanowire network had a...

article

A case of femoral hemorrhage in a patient with microscopic polyangiitis with low levels of myeloperoxidase-antineutrophil cytoplasmic autoantibody

Masanori Abe, Kazuyoshi Okada, Noriaki Maruyama, Shiro Matsumoto, more

Clinical and Experimental Nephrology > 2011 > 15 > 3 > 414-418

We present the case of a 67-year-old female with femoral hemorrhage accompanied by microscopic polyangiitis. She was admitted to our hospital with symptoms of general fatigue, fever, and edema of the lower limbs. She was diagnosed with microscopic polyangiitis on the basis of the cardinal symptoms of the condition, including rapidly progressive glomerulonephritis and the presence of myeloperoxidase-antineutrophil...

article

Characterization of Insulin Adsorption Behavior of Dialyzer Membranes Used in Hemodialysis

Masanori Abe, Kazuyoshi Okada, Kazuya Ikeda, Shiro Matsumoto, more

Artificial Organs > 35 > 4 > 398 - 403

Although it has been reported that plasma insulin is removed by hemodialysis (HD), the mechanism for this has not been elucidated. We investigated the mechanism of insulin removal during HD treatment and the characteristics of insulin removal with three high‐flux membranes. In our in vivo study, 20 stable diabetic patients on HD were randomly selected for three HD sessions with three different membranes:...

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Search results for: Kazuyoshi Okada

Splenic abscess diagnosed following relapsing sterile peritonitis in a peritoneal dialysis patient: A case report with literature review

Pulmonary sarcoidosis as a cause of intermittent fever of unknown origin in a hemodialysis patient with renal cell carcinoma: A case report and literature review

Sucroferric oxyhydroxide decreases serum phosphorus level and fibroblast growth factor 23 and improves renal anemia in hemodialysis patients

Intestinal perforation by a peritoneal dialysis catheter in which fungal peritonitis led to diagnosis: a rare case report

Cilostazol-induced acute tubulointerstitial nephritis accompanied by IgA nephropathy: a case report

Effects of a spleen tyrosine kinase inhibitor on progression of the lupus nephritis in mice

Efficacy and Safety of Pregabalin for the Treatment of Neuropathic Pain in Patients Undergoing Hemodialysis

Efficacy and safety of saxagliptin, a dipeptidyl peptidase-4 inhibitor, in hemodialysis patients with diabetic nephropathy: A randomized open-label prospective trial

Levocarnitine Improves Cardiac Function in Hemodialysis Patients With Left Ventricular Hypertrophy: A Randomized Controlled Trial

Association of restless legs syndrome with oxidative stress and inflammation in patients undergoing hemodialysis

Proposal for the Shared Decision‐Making Process Regarding Initiation and Continuation of Maintenance Hemodialysis

Japanese Society for Dialysis Therapy Clinical Guideline for “Hemodialysis Initiation for Maintenance Hemodialysis”

Low-density lipoprotein apheresis for corticosteroid-resistant skin lesions caused by cholesterol crystal embolism: a case report and review of the literature

Systematic implantation of dedifferentiated fat cells ameliorated monoclonal antibody 1-22-3-induced glomerulonephritis by immunosuppression with increases in TNF-stimulated gene 6

L/N-type calcium channel blocker cilnidipine reduces plasma aldosterone, albuminuria, and urinary liver-type fatty acid binding protein in patients with chronic kidney disease

Efficacy analysis of the renoprotective effects of aliskiren in hypertensive patients with chronic kidney disease

Aliskiren reduces home blood pressure and albuminuria in patients with hypertensive nephrosclerosis

Platinum nanowire network with silica nanoparticle spacers for use as an oxygen reduction catalyst

A case of femoral hemorrhage in a patient with microscopic polyangiitis with low levels of myeloperoxidase-antineutrophil cytoplasmic autoantibody

Characterization of Insulin Adsorption Behavior of Dialyzer Membranes Used in Hemodialysis

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