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ObjectiveCTLA‐4 is a negative regulator of the immune response expressed by regulatory T (Treg) cells and activated T cells. Polymorphisms in the CTLA4 gene have been associated with autoimmune diseases, including systemic lupus erythematosus. Disease‐associated polymorphisms have been shown to affect the production of the different CTLA‐4 variants through an effect on alternative splicing. This study...
ObjectiveSystemic lupus erythematosus (SLE) T cells display a hyperactive calcineurin/NF‐AT pathway. The aim of this study was to determine whether this pathway is responsible for the aberrant SLE T cell function and to test the effectiveness of the recently recognized calcineurin inhibitor dipyridamole in limiting SLE‐related pathology.
MethodsT cells and mononuclear cells were isolated from the...
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