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Based on the fact that site-specific amino acid replacement on peptide antigens stimulated T cell clones to produce increased amount of IFN-γ, we investigated this structure-function relationship, using various peptide analogues.We used three human Th0 clones (BC20.7,BC33.5 and BC42.1) that express distinct TCRα and TCRβ chains, but recognize the same TCR ligand ; i.e., the same framework of peptide...
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