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The understanding of protein folding and assembly is of central importance for the design of proteins and enzymes with novel or improved functions. Minimalistic model systems, such as coiled‐coils, provide an excellent platform to improve this understanding and to construct novel molecular devices. Along those lines, we designed a conformational switch that is composed of two coiled‐coil forming peptides...
Peptidische molekulare Leuchtfeuer , zusammengesetzt aus einer zentralen Bindesequenz (gelb) und zwei flankierenden Coiled‐coils bildenden Peptiden (rot), werden vorgestellt. Ihre geschlossene Konformation mit Haarnadel‐Struktur öffnet sich bei Bindung an einen Rezeptor (grau). In ihrer Zuschrift auf S. 17325 ff. berichten C. Mueller und T. N. Grossmann über diese neuartigen molekularen Schalter und...
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